The pathway enrichment analysis showed that the genes associated with the VMRs were enriched for 1,973 terms (FDR-adjusted P < 0.05) including 54 KEGG pathways with stronger evidence for neuroactive ligand-receptor interaction (hsa04080), breast cancer (hsa05224), pathways in cancer (hsa05200), hippo signalling pathway (hsa04390), Rap1 signalling pathway (hsa04015) and PI3K-Akt signalling pathway (hsa04151). The gene discussed is AKT1; the disease is breast cancer.