Confirmation qPCR in the ipsilateral hippocampus demonstrated that acute colitis following craniotomy (Sham+DSS) resulted in a trend for increased expression of neuroinflammatory (Tspo, Cybb, Gfap, Psmb9) and neuropathology (Mmp2) genes compared to water-treated Sham mice. The gene discussed is MMP2; the disease is colitis.