SETD2 and nonpapillary renal cell carcinoma: These observations, along with the frequent mutation of epigenetic regulators [dominated by SETD2 (2–16%), PBRM1 (1–43%), KDM5C (18%), and BAP1 (1–17%)] [4], emphasize the importance of epigenetic deregulation to the initiation and progression of ccRCC.