Consistent with identification of individual targeted methylation changes in the STS group, Ingenuity Pathway Analysis (IPA) of the 5744 genes revealed significant enrichment for EMT, while also highlighting type II diabetes mellitus signaling, and renin-angiotensin signaling (Fig. 2d, Additional file 1: Tables S3 and S5). The gene discussed is REN; the disease is type 2 diabetes mellitus.