Several of these genes are linked to epithelial-to-mesenchymal transition (EMT), which is central to ccRCC pathogenicity [28], including PRDM16, PTPRN2, and SLC12A7. The full list of genes, CpGs, and feature(s) they reside in is summarized in Additional file 1: Table S2. This evidence concerns the gene PTPRN2 and nonpapillary renal cell carcinoma.