Toll-like receptors (TLRs), especially TLR2 and TLR4, have been broadly reported to play detrimental roles following ischaemic stroke, and TLR2-deficient and TLR4-deficient mice have been shown to have neurological function protection after ischaemic stroke mediated by attenuation of the activation of T cells. Here, TLR2 is linked to ischemic stroke.