AKT1 and non-small cell lung carcinoma: Additionally, the p-AKT and p-ERK were totally not blocked by osimertinib even up to 1000 nM in mutEGFR NSCLC cells pre-incubated with H1299 cells-derived exosomes whereas there were moderate inhibition on p-AKT and dramatic decrease of p-ERK in control mutEGFR NSCLC cells (Fig. 3 d and e).