SNORD63 is located in chromosome 5q31.2 with a length of 68 nt and resides in intronic of HSPA9B, and functioned complementally by directing 2′-O-methylation of A531 in 28S rRNA residues [13]; Meanwhile, SNORD96A, located in chromosome 5q35.3 with a length of 72 nt and resides in intronic of GNB2L1, has been predicted to direct Gm75 (5.8S rRNA) [14], involved in cartilage ageing and osteoarthritis [15]. Here, RACK1 is linked to osteoarthritis.