F7 and Sepsis: The mechanisms underlying CAC remain poorly understood, but it can possibly result from activation of extrinsic coagulation pathway, leading to excess consumption of Factor-VII following endothelial cell infection by the virus [30, 31] Elevated D-dimer levels at the second evaluation time point were associated with higher mortality, likely reflecting coagulation activation from sepsis, “cytokine-storm”, or impending organ failure.