IL6 and Sepsis: Obviously, neutrophil activation markers are not as prone as pro-inflammatory cytokines to the effect of sample timing, and HBP has been suggested to be superior to IL-6 as a biomarker of sepsis.11 In a recent study, sepsis phenotypes were distinguished by inflammatory biomarkers, which were highest among the phenotypes with the highest mortality.35 As an early and relatively stable inflammatory biomarker, HBP may help to recognise high-risk sepsis patients.