In head and neck squamous cell carcinoma (HNSCC), a two-RBP gene signature (consisting of EZH2 and NOVA1) was constructed to predict the clinical prognosis of HNSCC patients, and this model will assist clinicians in providing a clinical diagnosis, individualized therapy, and prognostic assessment [35]. The gene discussed is EZH2; the disease is head and neck squamous cell carcinoma.