Based on our results, overexpression of LINC00485 significantly down-regulated the expression of mesenchymal markers N-cadherin and vimentin, whereas the expression levels of epithelial markers E-cadherin and cytokeratin were upregulated by directly modulating the miR-581/EDEM1 axis, suggesting that cancer cells lose their malignant phenotype. The gene discussed is CDH1; the disease is cancer.