Lower expression of LINC00485 contributed to the upregulation of miR-581 in CRC, promoting the proliferation, migration, and invasion of CRC cells, which was consistent with previous studies indicating that the up-regulation of miR-581 regulated the SMAD7/TGFβ signaling pathway, driving CRC metastasis [29]. The gene discussed is TGFB1; the disease is colorectal carcinoma.