Although a previous research observed an upregulation of both osteocytic and myocytic FGF23 expression in post-MI mice [33], recent evidence indicates that conditional ablation of FGF23 in bone cells only resulted in moderate reduction in circulating FGF23 levels [34, 35] and cardiac fibroblasts (not the bone or macrophages) were reported to be the only source of local FGF23 production after MI [7]. The gene discussed is FGF23; the disease is myocardial infarction.