In this study, we found that activation of FGF23/FGFR4 signaling pathway promotes renal fibrosis, which was mitigated by either PD173074 or BLU9931, a FGFRs non-specific inhibitor or a FGFR4 specific inhibitor, a loss of function experiments of FGF23 (such as knockdown of FGF23 in heart) would strengthen this conclusion. Here, FGF23 is linked to renal fibrosis.