LCN2 and fibrosis: Induction of MI for 12 weeks induced cardiac remodeling, myocardial fibrosis, cardiac dysfunction as well as kidney damage with glomerular and tubulointerstitial fibrosis accompanied by increased renal tissue neutrophil gelatinase-associated lipocalin (NGAL), elevated serum creatinine and upregulated the gene expression of Collagen I and Vimentin in the kidneys (Figure 1D–1J).