NOS3 and neoplasm: It has been reported in the literature that the sitosterol (MOL042) was capable of regulating the expression of some proteins in the VEGF signaling pathway to prevent tumor cells migrate [49], such as eNOS, PKC and P38, etc. eNOS, which is produced by endothelial cells, is a key factor in regulating vascular function because it produces nitric oxide that causes vasoconstriction.