In addition, we built an expression heatmap of 89 potential targets of Epimedium active components and based on the correlation analysis of the expression matrix, we found that the degree of association among overlapping genes in the Venn diagram was significantly higher, such as DAPK1, MAPK14, CDK2, LDHA, CYP1A2, etc. These well-correlated targets are closely related to NSCLC. The gene discussed is MAPK14; the disease is non-small cell lung carcinoma.