In addition, we built an expression heatmap of 89 potential targets of Epimedium active components and based on the correlation analysis of the expression matrix, we found that the degree of association among overlapping genes in the Venn diagram was significantly higher, such as DAPK1, MAPK14, CDK2, LDHA, CYP1A2, etc. These well-correlated targets are closely related to NSCLC. Here, DAPK1 is linked to non-small cell lung carcinoma.