Consistent with previous reports, we confirmed that the CASP model of sepsis promotes cardiac apoptosis, as evidenced by an enhanced ratio between pro‐ and anti‐apoptotic proteins, Bax and Bcl2, respectively (Bax/Bcl2), a decrease in mitochondrial cytochrome C levels, a significant decrease in mitochondrial membrane potential and by an increase in TUNEL staining. Here, CYCS is linked to Sepsis.