Mechanistically, we found that MIR4435‐2HG directly sponged miR‐513a‐5p, which was down‐regulated in ccRCC, and promoted KLF6 expression by disrupting the interaction between miR‐513a‐5p and KLF6 in ccRCC. Here, KLF6 is linked to nonpapillary renal cell carcinoma.