Variants in genes such as SNCA (synuclein alpha, encoding α-Syn), GBA (glucosylceramidase beta, encoding GBA protein), LRRK2 (leucine-rich repeat kinase 2, encoding LRRK2 protein), and MAPT (microtubule associated protein, encoding Tau) have been found to increase the risk of PD (Bras and Singleton 2009). The gene discussed is MAPT; the disease is Parkinson disease.