To study the functions of macrophage IKKβ in atherosclerosis, we previously generated LDLR−/− mice with myeloid-specific IKKβ deficiency (IKKβΔMyeLDLR−/−) mice by crossing IKKβΔMye (LysM-Cre/IKKβF/F) mice with LDLR−/− mice [26]. Here, LDLR is linked to atherosclerosis.