ICOSLG and infection: Overall, our data employing a blocking monoclonal anti-ICOSL antibody in the context of the acute MCMV infection revealed a high importance of the ICOSL:ICOS axis in the formation of Tfh cells and subsequent GC B-cell development in spleens and lymph nodes follicles, consistent with what has been previously observed in other in vivo experimental models of infection (Wikenheiser and Stumhofer, 2016).