In HFD‐induced zebrafish models of T2DM, autophagy‐related genes, including Atg3, Atg4B, Atg7, and Foxo3, were all shown to be expressed at low levels; levels of the autophagy inhibitor gene m‐TOR were increased, and downstream insulin signals were impaired.32 This evidence concerns the gene FOXO3 and type 2 diabetes mellitus.