In the previous study, we found that G‐CSF significantly enhanced the levels of beclin‐1 and LC3 II/I ratio in DB/DB mice and reversed increases in the levels of NF‐κB, spatial memory, cognition was improved and the hippocampal atrophy of DB/DB mice were significantly ameliorated.39 This evidence concerns the gene BECN1 and hippocampal atrophy.