This substrate‐specific regulation of TFEB by the mTORC1 pathway has a crucial role in Birt–Hogg–Dubé syndrome, a disorder characterized by benign skin tumors, lung, and kidney cysts and renal cell carcinoma (Kauffman et al, 2014; Calcagnì, et al, 2016) and caused by mutations in the lysosomal RagC/D activator folliculin (FLCN) (Napolitano et al, 2020). Here, FLCN is linked to Complex Cyst of Kidney.