Mucopolysaccharidosis plus (MPS‐plus), characterized by typical manifestations of mucopolysaccharidoses such as coarse facial features, skeletal abnormalities, hepatosplenomegaly, respiratory problems, and by remarkable levels of glycosaminoglycans excretion in urines (Kondo et al, 2017), was associated with mutations in the VPS33A gene (Pavlova et al, 2019). This evidence concerns the gene VPS33A and mucopolysaccharidosis.