Notably, the results revealed that the epigenetic signature was tightly linked with mRNA expression levels of PD‐L1, PD‐1, CTLA‐4,26 TGFβ1/2/3,27 CCL5,28 IL‐10,29 CSF‐1, and CSF‐1R,30 highlighting an elevated immune suppressive microenvironment in these tumor samples (Figure 5G and S6C). This evidence concerns the gene TGFB1 and neoplasm.