Furthermore, knockdown of CXCL5 or CXCR2 attenuated cell proliferation, clonogenesis, migration/invasion and induced apoptosis in PC cell lines, suggesting autocrine CXCL5/CXCR2 signaling axis might be crucial to promote cell proliferation, tumorigenicity, migration/invasion and apoptosis escape in PC. The gene discussed is CXCR2; the disease is pachyonychia congenita.