TUBB and Lissencephaly: Mutations in several genes encoding alpha-tubulin (TUBA1A), beta-tubulin (TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB), and gamma-tubulin (γ-tubulin) (TUBG1) isoforms have been associated with a wide range of brain malformations including lissencephaly, polymicrogyria, microlissencephaly, and simplified gyration (Romaniello et al., 2018).