Animal studies have previously found that ibuprofen upregulated ACE2 protein in diabetic rats,70 whereas drugs such as ACE inhibitors and angiotensin II type-I receptor blockers had previously been associated with downregulation of ACE2.96 Upregulation of ACE2 may facilitate host infection, providing an increased cell entry point for SARS-CoV-2. The gene discussed is ACE2; the disease is infection.