This involves induction of phosphorylation of elongation initiation factor 2α (eIF2α) that suppresses translation, blocking the ability of virus to produce the viral coat proteins they need for replication.5 Induction of eIF2α phosphorylation is known to promote pain in a number of pathological conditions associated with sensory neuropathy.7,36,102 To our surprise, we noted that type I interferons did not induce an eIF2α-mediated response in nociceptors. Here, EIF2A is linked to sensory peripheral neuropathy.