Finally, we will discuss the evidence for neurotropism of SARS-CoV-2 and the possibility for direct viral infection of nociceptors through angiotensin-converting enzyme 2 (ACE2) receptors, proteases such as furin,18 and additional host entry receptors neuropilin 1 and 2 (NRP1 and NRP2).13,19 We think that these insights can inform how clinicians approach dealing with persistent pain and/or neuropathies in patients who suffer or have suffered from COVID-19. This evidence concerns the gene ACE2 and viral infectious disease.