It has been reported that Huaiqihuang, which contains mostly HE, reduces ERS by decreasing the podocyte GRP78 and CHOP expression and protects mice against high glucose-induced podocyte damage [31] and cisplatin-induced nephrotoxicity by inhibiting the apoptosis of renal tubular epithelial cells [21]. The gene discussed is DDIT3; the disease is hereditary elliptocytosis.