VEGFA and neoplasm: Furthermore, the adrenergic stimulation of dendritic cells enhances Th2-associated inflammation and Th17 differentiation, suppressing at the same time the antitumor activity of NK cells and stimulating tumor-associated macrophages to produce pro-inflammatory and pro-angiogenic factors such as the vascular endothelial growth factor (VEGF) and metalloproteinases [27].