Moreover, the sustained release of catecholamines, including norepinephrine, promotes the upregulation and activation of cAMP response element-binding protein (CREB), Phospholipase C, Protein Kinase Cα, Signal transducer and activator of transcription 3 (STAT3), the prolactin hormone and the prostaglandin E2 (PGE2) synthesis, all known to promote proliferation, migration, angiogenesis and apoptosis evasion in several cancers [2–5, 23–25]. Here, CREB1 is linked to cancer.