POI: premature ovarian insufficiency; POR: poor ovarian response; PRP: platelet-rich plasma; FSH: follicle-stimulating hormone; AMH: anti-Müllerian hormone; IVF: in vitro fertilization; USG: ultrasonography; AFC: antral follicle count; ICSI: intracytoplasmic sperm injection; ET: embryo transfer. The gene discussed is BRD2; the disease is premature menopause.