Except for the cohort of women with poor ovarian reserve (p-value=0.1342), all other cohorts were having a statistically significant decrease in serum FSH level (p-values of <0.0001, 0.0024, and <0.0001 for cohorts of premature ovarian insufficiency, perimenopause, and menopause respectively). The gene discussed is BRD2; the disease is Premature ovarian insufficiency.