Similarly, when metastatic rectal cancer cases were compared with stage II rectal tumors, a 7.14-fold difference in ALDH1, -1.22-fold change in E cadherin, 2.07-fold change in vimentin, and 5.05-fold change in Twist (P=0.015) were reported. The gene discussed is ALDH1A1; the disease is rectal neoplasm.