APOE and Alzheimer disease: Other causes include cerebrovascular disease, increased blood pressure, increase insulin resistance in type two diabetes mellitus, bodyweight, metabolic syndrome, smoking, traumatic brain injury, plasma lipid levels, diet, intellectual activity, and decreased physical activity [4]. Research focusing on the genetic component of Alzheimer's disease shows that Individuals with the apolipoprotein E4 (ApoE4) allele are at a higher chance of the disease [5-7].