MAPT and Alzheimer disease: Some say LDL-C, TC is associated with increased tau concentration, according to some LDL-C, TC cause increased amyloid build-up, and some found that LDL and TC disrupt the cell cycle [38]. A study by Liu et al., including around 2333 AD patients and 3615 healthy controls, also suggested the association between LDL-C, TC, and AD [39]. Two studies also found that cholesterol remains normal, and only the serum triglyceride level is increased in the case of AD [22,40].