TNFRSF9 and neoplasm: This synergy between vaccination and anti-4-1BB antibody was reported previously in the same tumor model albeit via intranasal instillation of peptide and α-GalCer mixtures conferring higher cytotoxic potential to T cells but did not demonstrate any benefit from anti-PD-1 antibody treatment.27 Here, we observed synergistic effects of both combinatorial approaches in the same tumor model via intravenous administration of nanoparticles containing 10 fold less peptide and iNKT cell agonists.