In addition to EZH2,SUZ12, and EED overexpression, the activityof the PRC2 complex can be enhanced by GOF mutations in the methyltransferasedomain of EZH2. Such mutations have been described in specifictypes of non-Hodgkin lymphomas (diffuse large B-cell lymphoma (DLBCL) andfollicular lymphomas) [129, 221, 239-245](Fig. 4).Point Y641→F,N,H,S substitutions relative toisoform C (denoted as Y646 relative to isoform A) are the most common mutations[129, 221, 239, 242-245]. Here, SUZ12 is linked to diffuse large B-cell lymphoma.