CASP3 and neoplasm: Western blotting showed that the expression of cleaved caspase-3 was significantly weaker in Tg tumors than in non-Tg control tumors, while the proliferating cell nuclear antigen (PCNA) expression in Tg tumors was stronger than non-Tg control tumors (Figure 3), indicating tumor apoptosis was suppressed and tumor proliferation was enhanced in Tg mice.