In the animal model, the growth arrest-specific 5 (GAS5) overexpression in CAD rats has been shown to inhibit abnormal activation of the Wnt/β-catenin signaling pathway, leading to improvement of hyperlipidaemia, attenuation of myocardial injury, inhibition of cardiomyocyte apoptosis, and reduction of oxidative stress [138]. The gene discussed is GAS5; the disease is hyperlipidemia.