SOD1 and coronary artery disorder: Supplementation with L-carnitine at a dose of 1000 mg/d after 12 weeks reduces oxidative stress (MDA level by 7%) and increases the activity of antioxidant enzymes (CAT by 16%, SOD by 47%, and GPx by 12%) in patients with CAD [143], while the administration of doses higher than 2000 mg/d showed a cardioprotective effect and reduced mortality rates in CAD patients [144].