In patients who have a BMI increase, suffer from CAD and will undergo CABG, increased ROS levels, increased expression of ROS-producing enzymes (P47phox, xanthine oxidase), decreased expression of antioxidant enzymes (mitochondrial aldehyde dehydrogenase, heme oxygenase-1, and eNOS), and increase in markers of inflammatory processes in serum and right atrial myocardial tissue (sVCAM-1 and CCL5/RANTES) have been demonstrated [115]. This evidence concerns the gene CCL5 and coronary artery disorder.