ACE and diabetic kidney disease: I/D polymorphism of АСЕ gene is associated with ACE blood level and determines the onset of such diseases as coronary heart disease, left ventricular hypertrophy, arterial hypertension, stroke, diabetic nephropathy, type 2 diabetes mellitus, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy and hypertensive retinopathy, according to different research [35, 38–46].