The ADAURA study is a double-blind, randomized phase III study evaluating the efficacy and safety of adjuvant osimertinib (a CNS active third-generation EGFR tyrosine kinase inhibitor) vs. placebo in 682 patients with EGFR-mutated (del19/L858R) stage IB–IIIA NSCLC after complete tumor resection, for a maximum of 3 years. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.