Therefore, in recent years, various early specific biomarkers of kidney damage have been studied, among which much attention is paid to cystatin C. In 2005, Deo et al., having compared serum creatinine and cystatin C levels with GFR, found that cystatin C is a more accurate marker of renal function damage than creatinine [35]. The gene discussed is CST3; the disease is Nephropathy.