CST3 and chronic kidney disease: Studies by the Multi-Ethnic Study of Atherosclerosis (MESA) (2014) and Cardiovascular Health Study (CHS) (2009), which included 11,909 people with CKD, showed that cystatin C, not creatinine, and GFR indicators calculated based on it play an important prognostic role in the identification of individuals with a high risk of vascular complications [36].