Analysis of publicly available datasets using gene set enrichment analysis (GSEA) 48, 49 revealed that the Hsp-associated gene sets were significantly enriched in the putative CSC populations of lung (GSE38678), colon (GSE24747), and breast (GSE67966) cancers and in the tumors derived from patients with lung adenocarcinoma (GSE41271), colon cancer (GSE17537), and breast cancer (GSE58812) with recurrence (GSE41271 and GSE17537) or metastasis (GSE58812) [false discovery rate (FDR) < 0.25] (Figure 1F, S6B). This evidence concerns the gene HSP90B2P and cancer.