Based on the role of the HSP system in stabilization of various oncoproteins in multiple types of cancer cells 35, the impact of the HSP system on CSCs, especially that controlled by HSP70 18, 19, the reported toxicities of HSP90 inhibitors 21, and cancer cell resistance to HSP90 inhibitors 51, we have attempted to develop effective inhibitors of the HSP system, especially those targeting HSP70, as a strategy to eradicate both non-CSC and CSC populations. The gene discussed is HSP90AA1; the disease is cancer.