The result was also confirmed with another online platform of Lawlor et al. (https://shinyapps.jax.org/endoc-islet-multi-omics/) (Figure 4A), suggesting the enrichment of active transcription start sites at the Smad3 genomic sequence in islet of type 2 diabetes patients is valid across different databases. The gene discussed is SMAD3; the disease is type 2 diabetes mellitus.