Furthermore, by a conditional knockout of Lpin1 in Schwann cells (SCs) in mouse (MPZcre+/LpfE2-3/fE2-3), Nadra et. al.9 demonstrated that ablation of Lpin1 is sufficient to cause peripheral neuropathy; as well as endoneurial accumulation of phosphatidate in adipose tissues and peripheral nerves, which in turn lead to activation of MEK-Erk pathway and demyelination in SCs. Here, LPIN1 is linked to peripheral neuropathy.