LDLRAD3 and pachyonychia congenita: A high level of circ-LDLRAD3 was positively associated with tumor venous invasion (p=0.025) and lymphatic metastasis (p=0.014) 122, and its expression in plasma was significantly related to CA19-9 levels (p=0.03), N stage (p=0.049), venous invasion (p=0.005), and lymphatic metastasis (p=0.014) in PC tissues 122.