PAK1 and pachyonychia congenita: Xu et al. discovered that elevated circSFMBT1 (hsa_circ_0066147) enhanced the proliferation, invasion, migration, and EMT process of PC cells and inhibited the apoptosis of PC cells in vitro by regulating the miR-330-5p/PAK1 pathway by sponging miR-330-5p 113.