In summary, our study demonstrates that JMJD3 is induced in mouse models of renal fibrosis induced by UUO and SNx, and inhibition or loss of JMJD3 aggravates renal fibrosis by allowing activation of multiple profibrotic signaling pathways that otherwise would have been suppressed by JMJD3 demethylation of H3K27me3 as indicated in Figure 8. Here, KDM6B is linked to renal fibrosis.