Studies by our group and others demonstrated that reduction of H3K27me3 expression levels by either pharmacological or genetic inhibition of its methyltransferase, EZH2, results in attenuation of renal fibrosis, peritoneal fibrosis, acute kidney injury and lupus, but aggravation of podocyte injury in diabetics 14-19. The gene discussed is EZH2; the disease is renal fibrosis.