The role of KDM6A in protection of CML cells against imatinib is not cell line dependent as knockdown of KDM6A also sensitized MEG-01 CML cells that carry wild-type BCR-ABL to imatinib-induced apoptosis (Figure 1E and Figure S2A). This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.