DUBs are classified into 7 families including USPs (ubiquitin-specific proteases), UCHs (ubiquitin carboxy-terminal hydrolases), OTUs (ovarian tumor proteases), MJDs (Machado-Josephin domain-containing proteases), MINDYs (motif-interacting with ubiquitin-containing novel DUB family), JAMMs (the JAB1, MPN, MOV34 family) and ZUP1 (zinc finger containing ubiquitin peptidase 1) 11, 12. This evidence concerns the gene COPS5 and ovarian neoplasm.