Among 90 candidates, ten DUBs (PSMD14, TNFAIP3, JOSD1, UFD1L, UCK2, SENP5, COPS5, USP5, USP31 and USP39) were found to be significantly increased in HNSCC using bioinformatics analysis. This evidence concerns the gene UFD1 and head and neck squamous cell carcinoma.