Results of in vivo orthotopic CRC assays also showed that ITGB3 overexpression not only reversed the impaired metastatic capacity of Caco-2-CXCL12 cells mediated by HOXB5 knockdown but also shortened the overall survival time of the nude mice (Supplementary Figure S5C-I). The gene discussed is CXCL12; the disease is colorectal carcinoma.