Through interacting with the 5'/3'UTR regions of Hexokinase 2 (HK2) and the 3'UTR region of Glucose transporter 1 (GLUT1, also known as SLC2A1), METTL3 stabilized HK2 and GLUT1 transcripts to activate the glycolysis pathway and then promote CRC tumorigenesis 41. The gene discussed is HK2; the disease is colorectal carcinoma.