METTL14 induced methylation of lncRNA XIST as well as mRNA SOX4 to downregulate their expression via YTHDF2-mediated RNA degradation 43,44 METTL14 also suppressed CRC cell growth via miR-375/YAP1 pathway as well as inhibited CRC cell migration and invasion via miR-375/SP1 pathway 45. This evidence concerns the gene SP1 and colorectal carcinoma.