IHC staining revealed that αPD-L1 Ab in combination with NPs-Stattic-IL20RA inhibited the expression of p-STAT3 (Tyr705) and SOX2 in tumor tissues compared with IgG, αPD-L1 Ab, NPs-Stattic, and NP-Stattic-IL20RA plus IgG treatment, respectively (Figure 6F). This evidence concerns the gene SOX2 and neoplasm.