After extracting the expression data of 232 autophagy-related genes in HNSCC patients,10 downregulated genes (NRG2, NRG3, MAP1LC3C, PRKN, HSPB8, CCL2, FOS, TP53INP2, PTK6, and NKX2-3) and 28 upregulated genes (EIF4EBP1, BAK1, RGS19, HIF1A, CXCR4, CTSL, VMP1, SPNS1, TNFSF10, TP63, BID, VEGFA, SPHK1, EGFR, SERPINA1, DDIT3, EIF2AK2, ITGB4, ITGA3, APOL1, IRGM, BIRC5, FADD, ITGA6, IFNG, NRG1, IL24, and CDKN2A) were determined. This evidence concerns the gene IRGM and head and neck squamous cell carcinoma.