EGFR, FADD, and ITGA3 were upregulated in the high-risk group (Figures 6(a), 6(e), and 6(f)), which indicated they acted as risk factors, while HSPB8 and CDKN2A were discovered to be downregulated in the high-risk group (Figures 6(b) and 6(d)), indicating that they were protective factors for HNSCC. The gene discussed is ITGA3; the disease is head and neck squamous cell carcinoma.