These results indicated that combinatorial cisplatin and moxibustion elevated the numbers of infiltrating CD8+ CTLs, CD4+ T, Th1, Th2, Th9 cells, Tregs, and M1 macrophages, as well as the expression of the Cd69, Ifng, and Cd86 genes in the tumor microenvironment. This evidence concerns the gene CD69 and neoplasm.