CD8A and neoplasm: In the present study, we focused first on the action of moxibustion on the tumor immune microenvironment finding that moxibustion and combinatorial therapy promoted the infiltration of Th1 cells as well as the gene expression of Cd69 (a major marker of T cell activation) and the related cytokine Ifng. Furthermore, combinatorial therapy could promote the infiltration of CD8+ CTLs, CD4+ T cells, and Th9 cells (triggering CD8+ CTLs-mediated anti-tumor immunity through secretion of IL-9 and IL-21) in the tumor (Figures 2(c)–2(d)).