Interestingly, we have previously argued in support of the involvement of DMBX1 in the etiology of autosomal recessive intellectual disability based on the original family and a follow up family with the same founder (NM_147192.2:c.367C>T:p.(Arg123Trp) (Maddirevula et al., 2019b). This evidence concerns the gene DMBX1 and autosomal recessive non-syndromic intellectual disability.