Healen et al. have confirmed that cardiac-specific knockout of SAV1 can block the Hippo-YAP/TEAD1 signaling pathway, significantly reduce the level of Yap phosphorylation, and lead to cardiac hypertrophy, which has also been verified in MST1/2 and LATS2 knockout mice [28–30]. The gene discussed is LATS2; the disease is cardiac hypertrophy.