A previous study showed that pancreatic ductal adenocarcinoma (PDACs) cells that express an activated KRAS increase the expression of CA9, via stabilization of hypoxia-inducible factor 1 subunit alpha (HIF1A) and HIF2A, which eventually regulates the pH and glycolysis [25]. The gene discussed is EPAS1; the disease is pancreatic ductal adenocarcinoma.